Type I IFNs Act upon Hematopoietic Progenitors To Protect and Maintain Hematopoiesis during Pneumocystis Lung Infection in Mice.

B cells modulate systemic responses to Pneumocystis lung infection and 1 protect on - demand hematopoiesis via T cell - independent , innate 2 mechanism when type - I - IFN - signaling is absent

13 HIV infection results in a complex immunodeficiency due to loss of CD4 + T cells, impaired 14 type-I-IFN-responses and B cell-dysfunctions causing susceptibility to opportunistic infection 15 such as Pneumocystis pneumonia and unexplained comorbidities, including bone marrow 16 dysfunctions. Type-I-IFNs and B cells critically contribute to immunity to Pneumocystis lung 17 infection. We recen...

B cells modulate systemic responses to Pneumocystis murina lung infection and protect on-demand hematopoiesis via T cell-independent innate mechanisms when type I interferon signaling is absent.

HIV infection results in a complex immunodeficiency due to loss of CD4(+) T cells, impaired type I interferon (IFN) responses, and B cell dysfunctions causing susceptibility to opportunistic infections such as Pneumocystis murina pneumonia and unexplained comorbidities, including bone marrow dysfunctions. Type I IFNs and B cells critically contribute to immunity to Pneumocystis lung infection. ...

Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection.

Although acquired bone marrow failure (BMF) is considered a T cell-mediated autoimmune disease, possible innate immune defects as a cause for systemic immune deviations in response to otherwise innocuous infections have not been extensively explored. In this regard, we recently demonstrated an important role of type I IFNs in protecting hematopoiesis during systemic stress responses to the oppo...

Lung Infection Pneumocystis IFNs during Systemic Responses to and Regulation of Hematopoiesis by Type I Prevention of Bone Marrow Cell Apoptosis

Type I interferon signaling and B cells maintain hemopoiesis during Pneumocystis infection of the lung.

Loss of CD4 T cells is the hallmark of HIV infection. However, type I IFN-producing plasmacytoid dendritic cells may also be lost. This results in susceptibility to an opportunistic infection such as Pneumocystis pneumonia. In addition, regenerative bone marrow failure resulting in pancytopenia is another common problem in advanced stage AIDS. This may be linked to both the failing immune syste...